Setup is easy - just add a new instance with the URL to your monitoring system, your username and password. No server-side modification needed.
Centreon Example: https://example.com/centreon
checkmk Example: https://example.com/sitename/check_mk
Nagios Example: https://example.com/nagios/cgi-bin
Nagios XI Example: https://example.com/nagiosxi
Icinga API Example: https://example.com:5665
Icinga Web 2 Example: https://example.com/icingaweb2
Icinga Classic Example: https://example.com/icinga/cgi-bin
OP5 API Example: https://op5.example.com
OpsView API Example: https://opsview.example.com
Thruk 2.x Example: https://example.com/thruk/cgi-bin
Thruk API Example: https://example.com/thruk
You can choose between US (Default), EURO, ISO8601 and STRICT-ISO8601 date format, dependent on your monitoring configuration.
At instance setup you can also set a "default ack" message, which will be used for instant acknowledge.